Publications from Chen Lab:
# co-first; * co-corresponding.
Chen Lab members are underlined.
2024
Fan P#, Shang XY#, Song A#, Chen S#, Mao RY, Chen J, Wang Z, Zheng H, Tao B, Xu W, Jiang W, Yang H, Xu C, Zhang P*, Jiang H*, Chen FX*. Catalytic-independent functions of INTAC in conferring sensitivity to BET inhibition. bioRxiv. 2024. https://doi.org/10.1101/2024.02.07.579305
Xu C#*, Zhou QX#, Zheng H#, Song A#, Zhao WY, Xiong Y, Huang Z, Xu Y*, Cheng J*, Chen FX*. Stabilization of Integrator/INTAC by the small but versatile DSS1 protein. bioRxiv. 2024. https://doi.org/10.1101/2024.02.25.581915.
Shang XY, Xu C*, Chen FX*. From snapshots to a movie: Capturing eukaryotic transcription initiation at single-nucleotide resolution. Science Bulletin. 2024 Jan 23:S2095-9273(24)00057-4.
Wang J, Xu C, Zhang Z*, Chen FX*. Mechanisms of SOSS-Integrator-PP2A complex in attenuating R-loops and promoting genome stability. Clinical and Translational Medicine. 2024 Jan;14(1):e1519.
2023
Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*.R-loop-dependent promoter-proximal termination ensures genome stability. Nature. 2023 Aug 9. doi: 10.1038/s41586-023-06515-5.Featured in Molecular Cell, Cancer Discovery, Science Bulletin. BioArt, Fudan News.
Li C, Liao J, Wang X, Chen FX*, Guo X*, Chen X*.Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage. International Journal of Radiation Oncology, Biology, Physics. 2023 Jun 29:S0360-3016.
Zeng C#, Chen J#, Cooke EW, Subuddhi A, Roodman ET, Chen FX, Cao K.Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition.Nature Communications. 2023 Aug 22;14(1):4944. doi: 10.1038/s41467-023-40606-1.
Hu S#*, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX*. H3K4me2/3 modulate the stability of RNA polymerase II pausing. Cell Research. 2023 may;33(5): 403-406.
Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX*. INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II. Molecular Cell. 2023 Apr 11:S1097-2765(23)00212-5.
JiYX#, Hu S*, Chen FX*. Protocol for rapidly inducing genome-wide RNA Pol II hyperphosphorylation by selectively disrupting INTAC phosphatase activity. STAR Protocols. 2023 Oct 12;4(4):102640. doi: 10.1016/j.xpro.2023.102640.
Zheng H, Jin Q, Wang X, Qi Y, Liu W, Ren Y, Zhao D, Chen FX, Cheng J, Chen X, Xu Y.Structural basis of INTAC-regulated transcription. Protein Cell. 2023 Mar 4:pwad010. doi: 10.1093/procel/pwad010.
2022
Song A and Chen FX. The pleiotropic roles of SPT5 in transcription. Transcription. 2022 Jul 25;1-17. doi: 10.1080/21541264.2022.2103366.
Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX*, Xu Y*, Chen X*. RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Reports. 2022 Apr 26;39(4):110732.
Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX. Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1. Science Advances. 2022 Apr;8(13):eabm5504.
2021
Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX.SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape. Molecular Cell. 2021 Nov 4;81(21):4425-4439.e6. Featured in Nature Structural & Molecular Biology, BioArt, Fudan News.
2020
Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX*, Xu Y*. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science. 2020 Nov 27;370(6520):eabb5872. Featured in Faculty Opinions, Nature Reviews Molecular Cell Biology, BioArt, Fudan News.
· Research Highlight: Integrator of PP2A and transcription. Nature Reviews Molecular Cell Biology. 22, pages72–73 (2021).
Before 2020
Chen FX#, Smith ER, Shilatifard A*. Born to run: Control of RNA polymerase II transcription elongation. Nature Reviews Molecular Cell Biology. 2018 May 8. doi:10.1038/s41580-018-0010-5.
Chen FX#, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A*. PAF1 regulation of promoter-proximal pause release via enhancer activation. Science. 2017 Sep 22;357(6357):1294-1298.
Chen FX#, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A*. PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II. Cell. 2015 Aug;162(5):1003-1015. (Featured in Nature Reviews Molecular Cell Biology, “PAF1 regulates promoter-proximal pausing”)
Chen F#, Gao X, Shilatifard A*. Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide. Genes & Development. 2015 Jan 1;29(1):39-47.
Chen FX*#, Marshall SA, Deng Y, Tianjiao S. Measuring Nascent Transcripts by Nascent-seq. Methods in Molecular Biology. 2018;1712:19-26.
Chen F#, Yang H#, Dong Z#, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z*, Xu Y*. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Research. 2013 Feb;23(2):306.
Fang R#, Chen F#, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y*, Shi YG*. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Molecular Cell. 2013 Feb 7;49(3):558-70.
See full publication list on Google Scholar
